Apr 08, 2015 lymphocytic parotid gland enlargement in the hiv infection can be classified into three categories. Lymphoepitheliallike carcinoma of the parotid gland. The epithelial lining can be squamous, cuboidal or columnar, and although some cysts have pseudostratified ciliated epithelium, stratified squamous epithelium is the most common. Smears from a benign lymphoepithelial lesion are characterized by small clusters of ductal epithelial.
Lymphoepithelial cysts of the thyroid gland are rare lesions that are histologically similar to branchial cleft cysts found in the lateral neck. Case report primary lymphoepithelial carcinoma of the. An abdominal ultrasound showed a con tracted gallbladder with multiple calculi, a hydatid cyst of the liver and a welldefined 46mmhomogenous mass in the head of the pancreas which was reported as a pseudocyst. A rare case of lymphoepithelial cyst of the pancreas is reported. Introduction the lymphoepithelial cyst lec is a dysontogenic benign cyst originated from the epithelial remnant retained in lymphoid tissues during the embryogenesis, although it might also be. Cyst wall with lymphoid follicles and sebaceous glands. A lymphoepithelial cyst is a benign growth in the mouth that may cause pain or discomfort to the individual.
Lymphoepithelial cyst is an intrasalivary gland cyst with dense lymphoid tissue in the cyst wall. This is the first case report of lymphoepithelial cyst from india. The swelling can be asymptomatic, but mild pain can also be associated. The cyst appears encapsulated by the surrounding lymphoid tissue see figure 3. Lymphoepithelial cyst of the submandibular gland europe. Histopathology of the lymphoepithelial cyst of the pancreas revealed squamous epithelial lining with no malignant features. View enhanced pdf access article on wiley online library html view. Jul 15, 20 primary lymphoepithelial like carcinoma of the parotid gland is a rare tumour with an increased incidence among eskimos and orientals. Benign lymphoepithelial lesions are swellings of salivary glands caused by a reactive lymphoid infiltrate with follicular hyperplasia, which obliterates the acinar glandular tissue and causes proliferation and disruption of ductal epithelium. We describe a case of 66 year male, incidentally diagnosed as lymphoepithelial cyst of pancreas that was managed by enucleation. Oral lymphoepithelial cyst med oral patol oral cir bucal.
Branchial cleft or cervical lymphoepithelial cysts. Complete resection of the cystic lesion was done with preservation of the facial nerve. Lymphoepithelial cyst is a rare lesion of the oral cavity, with the mouth floor being the most common site of occurrence. Benign lymphoepithelial lesion is most likely to occur in adults around 50 years of age. Pdf benign lymphoepithelial cyst blc, also known as branchial cyst, is an. Benign lymphoepithelial lesions radiology reference article. The benign lymphoepithelial cyst and a classification system for lymphocytic parotid gland enlargement in the pediatric hiv population. Lymphoepithelial cyst definition of lymphoepithelial. Nov 18, 2010 lymphoepithelial cysts are rare pancreatic lesions of undetermined pathogenesis. To our knowledge, it is the first reported case of an intramasseteric. Benign lymphoepithelial lesion an overview sciencedirect. The unilocular cyst was filled with keratin, lined by mature, keratinizing squamous epithelium and. The histopathological examination revealed a cystic lesion covered by a parakeratinized stratified squamous epithelium, which presented in its fibrous capsule a.
Histopathology neck branchial cyst lymphoepithelial. Printable lymphoepithelial cyst of the pancreas surgical. Lymphoepithelial cyst of the pancreas, histopathology 10. Hivassociated salivary gland disease hivsgd typically presents with xerostomia andor swelling of the major salivary glands.
Benign lymphoepithelial cyst blc, also known as branchial cyst, is an. Hivassociated salivary gland disease is a lymphoid hyperplasia in the parotid and sometimes submandibular, gland with lymphoepithelial cyst and lymphoepithelial lesions in hiv positive patients. Histopathology neck branchial cyst lymphoepithelial cyst. Histopathology study confirmed the diagnosis of lymphoepithelial cyst. B, cyst contents that stain for mucicarmine can represent a diagnostic challenge. Lymphoepithelial cysts are rare pancreatic lesions of undetermined pathogenesis. Lecs occur commonly in the salivary glands 1 x 1 shaha, ar, dimaio, t, webber, c et al. The literature on this entity is limited to case reports or small series. Lymphoepithelial lesions of oral cavity a keywords. Microscopically the cyst content consisted of keratinous material and the walls were lined by mature squamous epithelium surrounded by dense lymphoid tissue. These benign tumors usually do not recur on a complete surgical removal. The benign lymphoepithelial cyst and a classification system.
The lymphoepiyheliail cyst has been associated with hiv infection as part of a diffuse infiltrative lymphocytosis syndrome. The cyst is formed by dilation of the epithelial crypt normally present in lymphoid tissue, producing a cyst lined by stratified squamous. Bedat b, genevay m, dumonceau jm, frossard jl, forget j, morel p, berney t. Lymphoepithelial cyst lec of the pancreas is a rare lesion of undetermined pathogenesis that had been documented almost exclusively in males. The lining is composed to 3e4 layers of squamoid epithelial cells with occasional mucous cells interspersed within. Immunohistochemistry showed diffuse reactivity for cd20 and cd3 in the lymphoid tissue and uniform positivity for cytokeratins in the squamous epithelium. Ten patients with surgically resected and pathologically proven lec, found in a single institution database between 2000 and 2015, were evaluated in a retrospective fashion. Scattered minor salivary gland acini are noted with the specimen.
Salivary gland pathology in hiv patients diagnostic. Bullous pemphigoid associated with a lymphoepithelial cyst. Introduction the lymphoepithelial cyst lec is a dysontogenic benign cyst originated from the epithelial remnant retained in lymphoid tissues during the embryogenesis, although it might also be related to branchial cleft epithelium 1,2. The histopathology examination showed a collapsed cyst wall with adjacent salivary gland and small reactive lymphoid tissue. The therapeutic approach of choice is the surgical treatment, which has rare cases of postoperative complications. The prognosis of oral lymphoepithelial cyst is generally excellent with appropriate treatment surgery of the condition. The appearances were those of a lymphoepithelial cyst. To our knowledge, it is the first reported case of an intramasseteric lymphoepithelial cyst. Case report of a parotid benign lymphoepithelial cyst. It is associated with lymphoid infiltration of salivary gland tissue, producing atrophy and destruction of the acini myoepithelial sialadenitis of the salivary gland is associated with an increased risk of lymphoma, but criteria that predict its development have not been. The histopathological features studied were type of the lining epithelium, cystic content, pattern of lymphoid tissue, type of adjacent anatomic. Additional and relevant useful information for oral lymphoepithelial cyst.
The cyst structure is identical to branchial cleft cyst branchial pouch cleft anomalies composed of lymphoid tissue with germinal centers and squamous lining epithelial lining is attenuated stratified squamous one or two cells to approximately seven cells in thickness or focal respiratorytype epithelium with ciliated or goblet cells. Butow, comparative study of the effect of antiretroviral therapy on benign lymphoepithelial cyst of parotid glands and ranulas in hivpositive patients, oral surgery, oral medicine, oral pathology, oral radiology, and endodontology, 111, 2, 205, 2011. Parotid lymphoepithelial cyst in a hiv negative individual. Surgical removal of deep facial lesions can be very deli. Role of endoscopic ultrasound guided fine needle aspiration sushil k ahlawat division of gastroenterology, university of medicine and dentistry of new jersey. Conclusion in some case, lymphoepithelial cysts may present a diagnostic dilemma. The benign lymphoepithelial cyst and a classification. Primary lymphoepitheliallike carcinoma of the parotid gland is a rare tumour with an increased incidence among eskimos and orientals. Lymphoepithelial cyst definition of lymphoepithelial cyst. He underwent a left superficial parotidectomy and the histopathology report indicated a benign lymphoepithelial cyst. May 11, 2007 histopathology neck branchial cyst lymphoepithelial cyst. Histopathological features of the 26 oral lymphoepithelial cysts. The material presents branchial cyst, lymphoepithelial cyst in histopathological image of neck. Journal of oral and maxillofacial pathology jomfp is the official.
Benign lymphoepithelial lesions bll or blel, also misleadingly known as aidsrelated parotid cysts arpc, are mixed solid and cystic lesions that enlarge the parotid glands, and are usually associated with cervical lymph node enlargement, and. As with all true cysts, it has an epithelial lining. Metwaly h, cheng j, idayonemochi h, ohshiro k, jen ky, liu ar, saku t. Dec, 2018 the prognosis of oral lymphoepithelial cyst is generally excellent with appropriate treatment surgery of the condition. The literature on this entity is limited to reports. Common symptoms reported by people with lymphoepithelial cyst. The cyst wall is formed by lymphoid tissue with germinal centers. In western countries, salivary gland lymphoepitheliallike carcinomas are uncommon and only 14 cases have been described so far.
A 66yearold woman presented to the ent clinic due to difficulty in swallowing persisting for approximately 1 year. In these populations, it is usually associated with epsteinbarr virus. Lymphoepithelial cyst of the pancreas navigation for this section. Newark, nj, usa summary lymphoepithelial cysts of the pancreas are extremely rare, benign, nonneoplastic cysts that may simulate pseudocysts or cystic.
Lymphoepithelial cysts of the thyroid gland archives of. Hivassociated benign lymphoepithelial cysts of the. Eusguided trucut biopsies may enable the diagnosis of. There is a predilection for gender with 6080% being female.
Magnetic resonance imaging revealed a cystic mass at right tonsil. Lymphoepithelial cyst of the pancreas lymphoepithelial cyst of the pancreas ramsden, k. The cervical lymphoepithelial or branchial cleft cyst usually presents as a unilateral, softtissue fluctuant swelling that typically appears in the lateral aspect of the neck, anterior to the sternocleidomastoid muscle, and becomes clinically evident late in childhood or in early adulthood. Branchial cyst lymphoepithelial cyst histopathology of. Histologically, lymphoepithelial cysts typically consist of multiple epithelial cysts accompanied by dense lymphoid tissue. Association between lymphoepithelial cysts of the pancreas and hiv infection. Lymphoepithelial cyst lec refers to a cyst that is lined by metaplastic squamous or columnar epithelium permeated by lymphoid cells. Pdf benign lymphoepithelial cyst, also known, as branchial cyst is an. Parotid swelling in patients with hiv is often associated with salivary gland disease, including benign lymphoepithelial cysts blecs. Benign lymphoepithelial cyst blc, also known as branchial cyst. Benign lymphoepithelial lesion, also known as benign lymphoepithelial cyst, is a rare benign lesion of the head and neck it should not be confused the lymphoepithelial lesion found in the gi tract. Computerisedtomographyctoftheabdomen demonstrateda lowdensity,welldefinedlesion measuring 51mmx35mm between the head.
Well circumscribed tan enlargement on the left posterior lateral border of the tongue. Extremely rare, nonneoplastic, true cyst lined by squamous epithelium with abundant lymphoid tissue histologically similar to branchial cleft cysts arising in the neck first described in 1985 pathologe 1985. Patients demographics, clinical presentation, comorbidities, imaging. A short case series james matthew lloyd williamson, newton acs wong, andrew d stickland departments of hepatopancreatobiliary surgery and histopathology, bristol royal infirmary, upper maudlin street, bristol, bs2 8hw introduction lymphoepithelial cysts are rare benign pancreatic.
Benign lymphoepithelial cyst blc, also known as branchial cyst, is an infrequent lesion usually occurs in the parotid gland or the lateral cervical area including lymph nodes. The purpose of the study was to investigate imaging features as well as pathologic and clinical findings of lymphoepithelial cyst lec of pancreas. Benign lymphoepithelial cyst of parotid gland journal of oral and. Lymphocytic parotid gland enlargement in the hiv infection can be classified into three categories. The presence of blec can serve as an indicator of hiv infection, and the diagnosis of hivassociated blec is usually based on clinical course, hiv. Most authors link the origin of thyroid lymphoepithelial cysts to solid cell nests, which are the remnants of the ultimobranchial body. The oral lymphoepithelial cyst is composed of a cystic cavity. Lymphoepitheliomalike carcinoma, abbreviated lelc, is a rare, poorly differentiated, malignant epithelial tumour it can be considered a subtype of squamous carcinoma aka squamous cell carcinoma. We report a case of a 49yearold man who presented with weight loss and diarrhea. Lymphoepithelial carcinoma of the parotid gland, mild enhancement degree on ct scan, low ki67 value, northern china, epsteinbarr virus positive introduction lymphoepithelial carcinoma lec is a rare form of malignant tumor marked by extensive stromal infiltration of lymphocytes and plasma cells. Lymphoepithelial cysts may grow to reach considerable sizes enough to cause facial deformities. Unusual occurrence of tongue sensorial disorder after. Eus with fna and trucut biopsy may enable the clinician to make a definitive diagnosis.
Approximately 1%10% of patients with hiv infection have been reported to have salivary gland enlargement. Lymphoepithelial cyst lec is the most commonly encountered congenital neck pathology in the lateral part of the neck. Read lymphoepithelial cyst of the pancreas, histopathology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Stanford medicine school of medicine departments surgical pathology criteria lymphoepithelial cyst of the pancreas navigation for this section. Oral lymphoepithelial cyst registered dental hygienist. Men are affected twice as often as women, with peak incidence in the fourth through seventh decades of life. Figure 1 the lining of a lymphoepithelial cyst is noted with dense lymphoid proliferation around the lining.
The cyst is formed by dilation of the epithelial crypt normally present in lymphoid tissue, producing a cyst lined by stratified squamous epithelium. Oral lymphoepithelial cyst registered dental hygienist rdh. We report a case of multiple lymphoepithelial cysts of the thyroid gland in a patient with severe chronic lymphocytic thyroiditis. In western countries, salivary gland lymphoepithelial like carcinomas are uncommon and only 14 cases have been described so far. Bullous pemphigoid associated with a lymphoepithelial cyst of. The cyst was lined by columnar epithelium with abundant, granular cytoplasm and densely eosinophilic oncocytic oxophilic change. Branchial cyst lymphoepithelial cyst histopathology of neck video a a a. C, resection of the same case demonstrating keratin debris within the cyst lumen. A lymphoepithelial cyst lec of the pancreas is a benign and rare lesion that is difficult to diagnose preoperatively based on imaging studies. Differential diagnosis lymphoepithelial cyst of the. Hivassociated benign lymphoepithelial cysts of the parotid.
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